The understanding of how alcohol damages the liver has expanded substantially over the
last decade. In particular, the genetics of alcoholism, the genesis of fatty liver, the role of …

The development of alcoholic liver disease (ALD) is a complex process involving both the
parenchymal and non‐parenchymal cells in the liver. The impact of ethanol on hepatocytes …

A large proportion of heavy drinkers develop serious alcoholic liver disease. Susceptibility to
alcoholic hepatitis and cirrhosis appears to be influenced by heredity, gender, diet, and co …

Since the Tsukamoto-French rat model of intragastric ethanol infusion was developed in
1985, it has proved to be the first rat model that induced progressive alcoholic liver injury …

In Western societies roughly 50% of all cases of liver cirrhosis are related to alcohol abuse.
The oxidative metabolite of ethanol, acetaldehyde, often in conjunction with viral or …

Research has substantiated the role of several mechanisms responsible for alcohol-induced
hepatotoxicity. These mechanisms include: oxidative stress and lipid peroxidation; …

Fibrosis is but one of a constellation of histologic features that characterize alcoholic liver
disease; others include steatosis, ballooning degeneration of hepatocytes, neutrophil …

Alcohol abuse is a main cause of liver fibrosis and cirrhosis in the western world. Although
the major mechanisms of fibrogenesis are independent of the origin of liver injury, alcoholic …

The article summarizes the proceedings of a symposium on recent advances in research on
the pathogenesis of alcoholic liver disease at the 2001 RSA meeting in Montreal, Canada …

Important mechanisms responsible for alcohol-induced liver injury include mitochondrial
damage and loss of ATP, formation of acetaldehyde-and other aldehyde-protein adducts …