Many colorectal cancers (CRCs) that exhibit microsatellite instability (MSI) are not explained
by MLH1 promoter methylation or germline mutations in mismatch repair (MMR) genes …

BACKGROUND & AIMS: Colorectal cancers (CRCs) with microsatellite instability (MSI) and
a mismatch repair (MMR) immunohistochemical deficit without hypermethylation of the …

Simple Summary A significant proportion of families with a clinical suggestion of Lynch
syndrome and screened for the known MMR genes remain without a molecular diagnosis …

Colorectal cancers (CRCs) with microsatellite instability‐high (MSI+) but without detectable
germline mutation or hypermethylation in DNA mismatch repair (MMR) genes can be …

An accurate algorithm is essential for effective molecular diagnosis of hereditary colorectal
cancer (CRC). Here, we have extended the analysis of 71 CRC cases suspected to be …

MD, a pioneer in the field, is an autosomal dominant hereditary cancer syndrome, which
accounts for upwards of 3% of all colorectal cancers, 1, 2 and is associated with an …

Simple Summary The most prevalent type of hereditary colorectal cancer is called Lynch
syndrome and it is characterized by a tumor phenotype called microsatellite instability (MSI) …

Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome attributable
to deleterious germline mutations in mismatch repair (MMR) genes. The syndrome is typified …

Background Patients with colorectal cancer (CRC) with mismatch repair-deficient (dMMR)
tumours without MLH1 methylation or germline MMR pathogenic variants (PV) were …

Lynch syndrome (LS) is caused by germline mutations in mismatch repair (MMR) genes,
resulting in microsatellite‐unstable tumours. Approximately 35% of suspected LS (sLS) …