Transcriptome studies have uncovered a plethora of non-coding RNAs (ncRNA) in
mammals. Most originate within intergenic regions of the genome and recent evidence …

Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …

Genomic analyses have demonstrated that although less than 2% of the mammalian
genome encodes proteins, at least two thirds is transcribed. Many nontranslated RNAs have …

Beyond coding for proteins, RNA molecules have well-established functions in the
posttranscriptional regulation of gene expression. Less clear are the upstream roles of RNA …

Accumulating evidence over the last decade has presented us with the intriguing
observation that the majority of eukaryotic genomes are pervasively transcribed to encode a …

Systematic transcriptome analysis has revealed that a vast majority of the mammalian
genome is transcribed into RNA, thus establishing the concept of “pervasive transcription.” …

The mammalian genome harbors thousands of long noncoding RNA (lncRNA) genes.
Recent studies have indicated the involvement of several of these lncRNAs in the regulation …

A large portion of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs).
While once thought of primarily as “junk,” recent studies indicate that a large number of …

The cell nucleus is highly organized and functionally compartmentalized. Double‐stranded
naked DNA is complexed with core histones and assembled into nucleosomes and …

Pervasive transcription of the mammalian genome produces hundreds of thousands of
noncoding RNAs (ncRNAs). Numerous studies have suggested that some of these ncRNAs …