What determines large-scale anatomy? DNA does not directly specify geometrical
arrangements of tissues and organs, and a process of encoding and decoding for …

Pattern formation, as occurs during embryogenesis or regeneration, is the crucial link
between genotype and the functions upon which selection operates. Even cancer and aging …

Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel
complex shapes. How cellular networks construct and repair specific anatomical outcomes …

A major goal of regenerative medicine and bioengineering is the regeneration of complex
organs, such as limbs, and the capability to create artificial constructs (so-called biobots) …

Patterns of resting potential in non-excitable cells of living tissue are now known to be
instructive signals for pattern formation during embryogenesis, regeneration and cancer …

In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

Transformative impact in regenerative medicine requires more than the reprogramming of
individual cells: advances in repair strategies for birth defects or injuries, tumor …

Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational
control over anatomical structure and function. Recent successes in manipulating cellular …

Establishment of shape during embryonic development, and the maintenance of shape
against injury or tumorigenesis, requires constant coordination of cell behaviors toward the …

Achieving control over cell behavior and pattern formation requires molecular-level
understanding of regulatory mechanisms. Alongside transcriptional networks and …