Multivalent gold nanoparticle–peptide conjugates for targeting intracellular bacterial infections

R Chowdhury, H Ilyas, A Ghosh, H Ali, A Ghorai… - Nanoscale, 2017 - pubs.rsc.org
Although nanoparticle-tagged antimicrobal peptides have gained considerable importance
in recent years, their structure–function correlation has not yet been explored. Here, we have …

Small synthetic peptides bioconjugated to hybrid gold nanoparticles destroy potentially deadly bacteria at submicromolar concentrations

G Palmieri, R Tatè, M Gogliettino… - Bioconjugate …, 2018 - ACS Publications
Synthetic antibacterial peptides are advanced weapons that scientists design and produce
to confront current threats of harmful and mortal pathogens, which could affect humans in …

Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium

JH Yeom, B Lee, D Kim, J Lee, S Kim, J Bae, Y Park… - Biomaterials, 2016 - Elsevier
Antimicrobial peptides (AMPs) are a promising new class of antibacterial compounds.
However, their applications in the treatment of intracellular pathogenic bacteria have been …

A peptide-nanoparticle system with improved efficacy against multidrug resistant bacteria

I Pal, D Bhattacharyya, RK Kar, D Zarena, A Bhunia… - Scientific reports, 2019 - nature.com
The recent rise of multidrug resistant microbial strains requires development of new and
novel therapeutic alternatives. In this study, we present a novel antibacterial system that …

Size-controlled synthesis of gold nanoparticles tethering antimicrobial peptides with potent broad-spectrum antimicrobial and antibiofilm activities

U Rajchakit, S Lamba, K Wang, N Lyons… - Molecular …, 2024 - ACS Publications
New antimicrobials are urgently needed to combat the rising global health concern of
antibiotic resistance. Antimicrobial peptides (AMPs) are one of the leading candidates as …

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model

A Rai, S Pinto, TR Velho, AF Ferreira, C Moita… - Biomaterials, 2016 - Elsevier
The increase in antibiotic drug resistance and the low number of new antibacterial drugs
approved in the last few decades requires the development of new antimicrobial strategies …

Combining antimicrobial peptides with nanotechnology: an emerging field in theranostics

SA Mohid, A Bhunia - Current Protein and Peptide Science, 2020 - ingentaconnect.com
The emergence of multidrug-resistant pathogens and their rapid adaptation against new
antibiotics is a major challenge for scientists and medical professionals. Different …

Insights into cell penetrating peptide conjugated gold nanoparticles for internalization into bacterial cells

M Kumar, W Tegge, N Wangoo, R Jain, RK Sharma - Biophysical chemistry, 2018 - Elsevier
Gold nanoparticles (AuNPs) functionalized with different biomolecules find extensive
application in therapy, clinical diagnosis and biomedical imaging. Herein, two derivatives of …

Orientational Nanoconjugation with Gold Endows Marked Antimicrobial Potential and Drugability of Ultrashort Dipeptides

Z Zhang, Y Chen, J Gao, M Yang, D Zhang, L Wang… - Nano Letters, 2023 - ACS Publications
Antibiotic resistance is a global threat. Antimicrobial peptides (AMPs) are highly desirable to
treat multidrug-resistant pathogen infection. However, few AMPs are clinically available, due …

The membrane-targeting mechanism of host defense peptides inspiring the design of polypeptide-conjugated gold nanoparticles exhibiting effective antibacterial …

W Zhang, Y Wu, L Liu, X Xiao, Z Cong… - Journal of Materials …, 2021 - pubs.rsc.org
Multidrug-resistant bacterial infections are a grand challenge to global medical and health
systems. Therefore, it is urgent to develop versatile antibacterial strategies that can combat …