Although several studies have suggested that anti-inflammatory strategies reduce
secondary infarct growth in animal stroke models, clinical studies have not yet demonstrated …

Background and Purpose—Therapeutic modification of the postischemic immune processes
is a key target of current experimental stroke research. For successful translation into the …

Background and Purpose—Ischemic stroke leads to significant morbidity and mortality in the
Western world. Early reperfusion strategies remain the treatment of choice but can initiate …

Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

Despite considerable efforts in research and clinical studies, stroke is still one of the leading
causes of death and disability worldwide. Originally, stroke was considered a vascular …

Stroke elicits excessive immune activation in the injured brain tissue. This well-recognized
neural inflammation in the brain is not just an intrinsic organ response but also a result of …

The immune system is rapidly activated after ischemic stroke. As immune cells migrate and
infiltrate across the blood-brain barrier into the ischemic region, a cascade of cellular and …