The effect of high glucose on lipid metabolism in the human placenta

CH Hulme, A Nicolaou, SA Murphy, AEP Heazell… - Scientific reports, 2019 - nature.com
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …

Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …

Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …

High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta

F Visiedo, F Bugatto, V Sánchez… - American Journal …, 2013 - journals.physiology.org
Placentas of women with gestational diabetes mellitus (GDM) exhibit an altered lipid
metabolism. The mechanism by which GDM is linked to alterations in placental lipid …

Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta

C Marseille‐Tremblay… - Molecular …, 2008 - Wiley Online Library
Maternal hypercholesterolemia (HC) during pregnancy and gestational diabetes mellitus
(GDM) are associated with disturbance of fetal development which may also modify key …

BMI-independent effects of gestational diabetes on human placenta

L Stirm, M Kovářová, S Perschbacher… - The Journal of …, 2018 - academic.oup.com
Purpose Recently, alterations in maternal lipid metabolism were associated with gestational
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …

Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus

T Radaelli, J Lepercq, A Varastehpour, S Basu… - American journal of …, 2009 - Elsevier
OBJECTIVE: Changes in metabolic homeostasis in pregnant diabetic women are potential
determinants of increased adiposity of the fetus. The aim of this study was to characterize …

Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition

MT Segura, H Demmelmair, S Krauss-Etschmann… - Placenta, 2017 - Elsevier
Introduction Placental fatty acid (FA) uptake and metabolism depend on maternal supply
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …

Glucose and fatty acid metabolism in placental explants from pregnancies complicated with gestational diabetes mellitus

F Visiedo, F Bugatto, R Quintero-Prado… - Reproductive …, 2015 - journals.sagepub.com
Placental metabolism is an important mechanism for the regulation of fetal growth and long-
term health of the newborns. In this study, we investigated the effects of maternal metabolic …

Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism

KL Bidne, AL Rister, AR McCain, BD Hitt… - Biology of …, 2021 - academic.oup.com
Dyslipidemia is a characteristic of maternal obesity and previous studies have demonstrated
abnormalities in fatty acid oxidation and storage in term placentas. However, there is little …