The effect of high glucose on lipid metabolism in the human placenta
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …
placental dysfunction, which has health consequences for the infant. Here we test our …
Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta
L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …
High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta
Placentas of women with gestational diabetes mellitus (GDM) exhibit an altered lipid
metabolism. The mechanism by which GDM is linked to alterations in placental lipid …
metabolism. The mechanism by which GDM is linked to alterations in placental lipid …
Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta
C Marseille‐Tremblay… - Molecular …, 2008 - Wiley Online Library
Maternal hypercholesterolemia (HC) during pregnancy and gestational diabetes mellitus
(GDM) are associated with disturbance of fetal development which may also modify key …
(GDM) are associated with disturbance of fetal development which may also modify key …
BMI-independent effects of gestational diabetes on human placenta
L Stirm, M Kovářová, S Perschbacher… - The Journal of …, 2018 - academic.oup.com
Purpose Recently, alterations in maternal lipid metabolism were associated with gestational
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …
Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus
T Radaelli, J Lepercq, A Varastehpour, S Basu… - American journal of …, 2009 - Elsevier
OBJECTIVE: Changes in metabolic homeostasis in pregnant diabetic women are potential
determinants of increased adiposity of the fetus. The aim of this study was to characterize …
determinants of increased adiposity of the fetus. The aim of this study was to characterize …
Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition
MT Segura, H Demmelmair, S Krauss-Etschmann… - Placenta, 2017 - Elsevier
Introduction Placental fatty acid (FA) uptake and metabolism depend on maternal supply
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …
Glucose and fatty acid metabolism in placental explants from pregnancies complicated with gestational diabetes mellitus
Placental metabolism is an important mechanism for the regulation of fetal growth and long-
term health of the newborns. In this study, we investigated the effects of maternal metabolic …
term health of the newborns. In this study, we investigated the effects of maternal metabolic …
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism
Dyslipidemia is a characteristic of maternal obesity and previous studies have demonstrated
abnormalities in fatty acid oxidation and storage in term placentas. However, there is little …
abnormalities in fatty acid oxidation and storage in term placentas. However, there is little …