Quantitative metabolomics is under intense development, and no commonly accepted
standard analytical technique has emerged, yet. The employed analytical methods were …

Metabolomics encompasses the study of small molecules in a biological sample. Liquid
Chromatography coupled with Mass Spectrometry (LC–MS) profiling is an important …

Targeted detection is one of the most important methods in mass spectrometry (MS)-based
metabolomics; however, its major limitation is the reduced metabolome coverage that results …

The term" omics" refers to any type of specific study that provides collective information on a
biological system. Representative omics includes genomics, proteomics, and metabolomics …

The metabolome is the terminal downstream product of the genome and consists of the total
complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

Introduction The field of metabolomics has expanded greatly over the past two decades,
both as an experimental science with applications in many areas, as well as in regards to …

Large-scale metabolomics is a powerful technique that has attracted widespread attention in
biomedical studies focused on identifying biomarkers and interpreting the mechanisms of …

Metabolite identification is still considered an imposing bottleneck in liquid chromatography
mass spectrometry (LC/MS) untargeted metabolomics. The identification workflow usually …

Background Untargeted metabolomics approaches based on mass spectrometry obtain
comprehensive profiles of complex biological samples. However, on average only 10% of …