Acute kidney injury (AKI) is a major clinical problem in which a critical vascular,
pathophysiological component is recognized. We demonstrated previously that …

Severe acute renal failure (ARF) remains a common, largely treatment-resistant clinical
problem with disturbingly high mortality rates. Therefore, we tested whether administration of …

Introduction Studies have shown that stem cells exert their therapeutic effects on acute
kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in …

Acute kidney injury (AKI) is a major clinical problem associated with high morbidity and
mortality. Likely due to its complex pathophysiology, therapies with a single pharmacological …

BACKGROUND: Ischemia and reperfusion injury (I/R) is the major cause of acute renal
failure (ARF) with high mortality rates. Because alternative therapies are needed, we …

Acute kidney injury (AKI) is a common clinical complication, associated with poor outcomes
and the development of chronic kidney disease. Despite major advances in the …

Background: Although renal tubular epithelium has a great capacity for repair it has been
suggested that the administration of mesenchymal stem cells may accelerate the recovery …

The potential role of mesenchymal stem cells (MSCs, also called mesenchymal stromal
cells) in endogenous repair and cell-based therapies for acute kidney injury (AKI) is under …

Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …

Background—Understanding the mechanisms of repair and regeneration of the kidney after
injury is of great interest because there are currently no therapies that promote repair, and …