Mutations in the DNA Mismatch Repair Proteins MutS and MutL of Oxazolidinone-Resistant or -Susceptible Enterococcus faecium
Mutations in mutS and mutL, which encode DNA mismatch repair (MMR) proteins, can
confer hypermutator phenotypes and may facilitate the emergence of mutational antibiotic …
confer hypermutator phenotypes and may facilitate the emergence of mutational antibiotic …
Detection of Oxazolidinone-Resistant Enterococcus faecalis and Enterococcus faecium Strains by Real-Time PCR and PCR-Restriction Fragment Length …
N Woodford, L Tysall, C Auckland… - Journal of clinical …, 2002 - Am Soc Microbiol
ABSTRACT A real-time PCR assay identified linezolid-resistant Enterococcus faecalis and
Enterococcus faecium isolates with a G2576U rRNA mutation. PCR-restriction fragment …
Enterococcus faecium isolates with a G2576U rRNA mutation. PCR-restriction fragment …
Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis
M Lobritz, R Hutton-Thomas, S Marshall… - Antimicrobial agents …, 2003 - Am Soc Microbiol
In vitro linezolid resistance was selected at a higher frequency in Enterococcus faecalis JH2-
2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to …
2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to …
Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2
L Boumghar-Bourtchaï, A Dhalluin… - Antimicrobial agents …, 2009 - Am Soc Microbiol
We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-
deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a …
deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a …
Molecular characterisation of linezolid resistance in two vancomycin-resistant (VanB) Enterococcus faecium isolates using Pyrosequencing™
B Saager, H Rohde, BS Timmerbeil, G Franke… - European Journal of …, 2008 - Springer
In this paper, we describe the phenotypic and molecular characteristics of two clinically
relevant, vancomycin-resistant (VanB), linezolid-resistant Enterococcus faecium isolates …
relevant, vancomycin-resistant (VanB), linezolid-resistant Enterococcus faecium isolates …
A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of …
Abstract Objectives The oxazolidinone-resistant Enterococcus faecalis E349 from a human
patient tested negative for the cfr gene and 23S rRNA mutations. Here we report the …
patient tested negative for the cfr gene and 23S rRNA mutations. Here we report the …
The role of mutators in the emergence of antibiotic-resistant bacteria
I Chopra, AJ O'Neill, K Miller - Drug Resistance Updates, 2003 - Elsevier
Bacteria contain a number of error prevention and error correction systems that maintain
genome stability. However, strains exhibiting elevated mutation frequencies have recently …
genome stability. However, strains exhibiting elevated mutation frequencies have recently …
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria
RT Cirz, FE Romesberg - Antimicrobial Agents and Chemotherapy, 2006 - Am Soc Microbiol
The emergence of drug-resistant bacteria poses a serious threat to human health. Bacteria
often acquire resistance from a mutation of chromosomal genes during therapy. We have …
often acquire resistance from a mutation of chromosomal genes during therapy. We have …
Characterization of Enterococcus faecium with Macrolide Resistance and Reduced Susceptibility to Quinupristin/Dalfopristin in a Japanese Hospital: Detection of Extensive …
N Isogai, N Urushibara, M Kawaguchiya… - Microbial Drug …, 2013 - liebertpub.com
Cross-resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics is
mainly mediated by the erm (erythromycin ribosome methylation) genes that encode 23S …
mainly mediated by the erm (erythromycin ribosome methylation) genes that encode 23S …
'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites
AAF Zayed, TM Essam, AGM Hashem… - Emerging microbes & …, 2015 - Taylor & Francis
Fluoroquinolone resistance is gradually acquired through several mechanisms. In particular,
chromosomal mutations in the genes encoding topoisomerases II and IV and increased …
chromosomal mutations in the genes encoding topoisomerases II and IV and increased …