Responses to the three major classes of asthma therapy, beta-agonists, leukotriene
antagonists and inhaled corticosteroids, demonstrate wide inter-individual variability …

Reversibility of airway obstruction in response to β 2-agonists is highly variable among
asthmatics, which is partially attributed to genetic factors. In a genome-wide association …

Abstract Purpose of Review Several genome-wide association studies (GWASs) of
bronchodilator response (BDR) to albuterol have been published over the past decade. This …

Asthma and asthma-related traits, including response to bronchodilator and glucocorticoid
drugs, are heritable traits. Our understanding of asthma genetics and pharmacogenetics has …

Patient response to asthma therapy is consistently observed to be heterogeneous.
Pharmacogenomics is the study of inherited differences in interindividual drug disposition …

Major classes of medication in asthma management include bronchodilating β2-agonists,
anti-inflammatory inhaled corticosteroids, leukotriene modifiers and theophyllines. However …

Asthma is a complex inflammatory disease that affects 300 million people worldwide. Safe
and effective drugs control the symptoms but heterogeneity in response is large and …

There are a number of ways in which understanding the genetic basis of either disease
pathogenesis or treatment response might be of value in the management of respiratory …

GGGGGG 00 LGGLGGLGLL GGGGLS Pharmacogenetics refers to the study of inherited
differences in drug metabolism and response (both therapeutic and adverse). This must be …

Asthma is characterized by reversible bronchial hyper-responsiveness and airway
inflammation, and encompasses a wide variety of patients with different clinical phenotypes …