The blood vessels of the pancreatic islets are of crucial importance for oxygen and
metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells …

Abstract Background/Aims: To obtain a selective marker to identify endothelial cells is
difficult, due to the heterogeneity of these cells. Most described markers perform well in …

An adequate revascularization is crucial for islet survival and function after transplantation.
Previous studies have suggested that islet revascularization is concluded within 14 days …

Transplantation of pancreatic islets reconstitutes glucose homeostasis in diabetes mellitus.
Before transplantation, islets are disrupted from the surrounding blood vessels by the …

BACKGROUND: Intraportally transplanted islets are avascular at the time of transplantation
and take up to 14 days to fully revascularize, during which time up to 60% of islet mass may …

OBJECTIVE: Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To
preserve its function, transplanted islets must be revascularized because arterial and …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet
endothelial cells (ECs), which can contribute to the formation of functional blood vessels …

Revascularisation of transplanted islets is an essential prerequisite for graft survival and
function. However, current islet isolation procedures deprive the islets of endothelial …