Neural stem cells generate distinct cell types for tissue formation and cell replacement
during development and throughout adulthood. Neural development and plasticity are …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Neurons are submitted to an exceptional variety of stimuli and are able to convert these into
high-order functions, such as storing memories, controlling behavior, and governing …

Postmitotic neurons are subject to a vast array of environmental influences that require the
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …

Unraveling the mechanisms by which neural stem cells generate distinct cell types remains
a central challenge in central nervous system (CNS) biology. Recent studies have shown …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Recent advances in chromatin biology have identified a role for epigenetic mechanisms in
the regulation of neuronal gene expression changes, a necessary process for proper …