Background: Early descriptive work and controlled family and adoption studies support the
hypothesis that a range of personality and nonschizophrenic psychotic disorders aggregate …

Prior family and adoption studies have suggested a genetic relationship between
schizophrenia and schizotypy. However, this has never been verified using linkage …

The presence of subclinical levels of psychosis in the general population may imply that
schizophrenia is the extreme expression of more or less continuously distributed traits in the …

Background Psychotic disorders and schizotypal traits aggregate in the relatives of
probands with schizophrenia. It is currently unclear how variability in symptom dimensions in …

Context Identifying susceptibility genes for schizophrenia may be complicated by phenotypic
heterogeneity, with some evidence suggesting that phenotypic heterogeneity reflects …

Objective Subthreshold psychosis risk symptoms in the general population may be
associated with molecular genetic risk for psychosis. This study sought to optimize the …

Genome-wide linkage studies, examining the relationship between the schizophrenia
syndrome (s) and possible susceptibility regions within the human genome have identified …

Most general population risk for schizophrenia is accounted for by common variations in the
genome, but each variant explains only a tiny fraction of increased risk. In contrast …

It has been known for a long time that schizophrenia and several related psychopathological
traits aggregate in families on a common genetic basis. Improved methodology of recent …

Research in genetic epidemiology has provided powerful evidence that genetic factors
contribute to the familial transmission of schizophrenia. However, the precise mode of …