Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …
environment, but we lack molecular and functional signatures of different microglial …
Organotypic brain slice culture microglia exhibit molecular similarity to acutely-isolated adult microglia and provide a platform to study neuroinflammation
ARD Delbridge, D Huh, M Brickelmaier… - Frontiers in Cellular …, 2020 - frontiersin.org
Microglia are central nervous system (CNS) resident immune cells that have been
implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their …
implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their …
Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
Genome‐wide expression profiling technology has resulted in detailed transcriptome data
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
O Uriarte Huarte, D Kyriakis, T Heurtaux… - Frontiers in …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
IM Chiu, ETA Morimoto, H Goodarzi, JT Liao… - Cell reports, 2013 - cell.com
Microglia are resident immune cells of the CNS that are activated by infection, neuronal
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …
Profiling microglia through single-cell RNA sequencing over the course of development, aging, and disease
S Pettas, K Karagianni, E Kanata, A Chatziefstathiou… - Cells, 2022 - mdpi.com
Microglia are macrophages present in the brain that function as the primary and most
important source of immune response in the central nervous system (CNS). Regardless of …
important source of immune response in the central nervous system (CNS). Regardless of …
A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease
Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …
neuroinflammatory disorders has accentuated the need to characterize their function in …
Analyzing microglial phenotypes across neuropathologies: a practical guide
M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
Microglia heterogeneity in the single-cell era
Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …
carrying out prominent and various functions during development and adulthood under both …