Obese persons with metabolic syndrome often have associated with salt-sensitive
hypertension, microalbuminuria, and cardiac dysfunction, and the plasma aldosterone level …

Background/Aims: Obesity and diabetes are intimately interrelated, and are independent risk
factors for kidney disease. Overactivation of mineralocorticoid receptor (MR) is implicated in …

Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR)
system to dominate long-term blood pressure control. It is also increasingly recognized as …

Recent clinical and experimental studies have shown that aldosterone is a potent inducer of
proteinuria and that mineralocorticoid receptor (MR) antagonists confer efficient …

Hypertension is a leading contributor to cardiovascular mortality worldwide. Despite this, its
underlying mechanism (s) and the role of excess salt in cardiorenal dysfunction are unclear …

The kidney has a central role in long-term control of blood pressure, and decreased kidney
function is a common but difficult-to-treat cause of hypertension. Conversely, elevated blood …

Objectives: To elucidate the roles that renal mineralocorticoid receptor–Rac1 interactions
and oxidative stress play in salt-induced hypertension and renal injury in prepubertal rats …

Obesity hypertension and metabolic syndrome have become major public health concerns.
Nowadays, aldosterone is recognized as an important mediator of cardiovascular and renal …

Experiments with hyperaldosteronemic animals suggest that, despite lowering plasma
aldosterone, salt worsens renal injury by paradoxical activation of the mineralocorticoid …

The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney
disease, involves mineralocorticoid receptor (MR) activation. We previously identified …