Immunopathobiology and therapeutic targets related to cytokines in liver diseases
Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …
Interleukins in chronic liver disease: lessons learned from experimental mouse models
L Hammerich, F Tacke - Clinical and experimental …, 2014 - Taylor & Francis
Interleukins represent a class of immunomodulatory cytokines, small intercellular signaling
proteins, that are critically involved in the regulation of immune responses. They are …
proteins, that are critically involved in the regulation of immune responses. They are …
Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies
Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular
carcinoma) represent one of the most common causes of death worldwide. A number of …
carcinoma) represent one of the most common causes of death worldwide. A number of …
[HTML][HTML] Interleukin-1 family cytokines: keystones in liver inflammatory diseases
L Barbier, M Ferhat, E Salamé, A Robin… - Frontiers in …, 2019 - frontiersin.org
The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …
[HTML][HTML] IL-6 pathway in the liver: from physiopathology to therapy
D Schmidt-Arras, S Rose-John - Journal of hepatology, 2016 - Elsevier
Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …
Cytokine-induced inflammatory liver injuries
IL-18 is a pleiotropic cytokine and is produced by various types of cells including activated
macrophages, particularly Kupffer cells. IL-18 has potential to activate inflammatory …
macrophages, particularly Kupffer cells. IL-18 has potential to activate inflammatory …
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy
ABSTRACT The interleukin 6 (IL6) family of proteins regulate important cellular processes
and act through a variety of signaling pathways via a shared gp130 receptor. In the liver …
and act through a variety of signaling pathways via a shared gp130 receptor. In the liver …
[PDF][PDF] Pathological functions of interleukin‐22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
It is well established that interleukin (IL)‐22 has hepatoprotective and antifibrotic functions in
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …
[HTML][HTML] Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
T Mchedlidze, M Waldner, S Zopf, J Walker, AL Rankin… - Immunity, 2013 - cell.com
Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …
[HTML][HTML] Immunity and fibrogenesis: the role of Th17/IL-17 axis in HBV and HCV-induced chronic hepatitis and progression to cirrhosis
FC Paquissi - Frontiers in Immunology, 2017 - frontiersin.org
Cirrhosis is a common final pathway for most chronic liver diseases; representing an
increasing burden worldwide and is associated with increased morbidity and mortality …
increasing burden worldwide and is associated with increased morbidity and mortality …