Cancer-associated fibroblasts (CAFs) have been considered to play an important role for
tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in …

Stromal cell‑derived factor 1α (SDF1α) and its receptor C‑X‑C chemokine receptor type 4
(CXCR4) have been reported to form an important chemokine signaling pathway. Our …

Scirrhous gastric cancer (SGC) exhibits aggressiveness of the rapid infiltrating tumor cells
with abundant fibroblasts. Experimental studies using SGC cell lines have obtained useful …

Background Hypoxia and inflammation tumor microenvironment (TME) play a crucial role in
tumor development and progression. Although increased understanding of TME contributed …

Given the important role of CXCR4 in cancer metastasis, microenvironmental factors that
modulate CXCR4 may have an impact on the process of tumor expansion. Hypoxia is a …

Hypoxia microenvironment, as a major feature of solid tumors, increases tumors progression
and metastasis. To research whether hypoxia influences the epithelial–mesenchymal …

Background Gastric cancer (GC) is one of the most common causes of cancer death.
Hypoxia is an important property of the tumor microenvironment of GC. Increasing evidence …

Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although
the treatment outcome of GC has improved, the survival of patients with GC at stages III and …

Substantial evidence suggests that the epithelial-mesenchymal transition (EMT) phenotype
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …

Gastric cancers are one of the most common gastrointestinal tumors with proclivity to
metastasis. Hypoxia is an important feature in solid tumor microenvironment; accumulating …