Nitric oxide (NO) can exert both protective and proinflammatory actions in the
gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates …

Nitric oxide (NO) plays important roles in gastrointestinal mucosal defence, as well as in the
pathogenesis of several gastrointestinal diseases (eg irritable bowel syndrome and …

Nitric oxide (NO) has been implicated as a modulator of blood flow, motility, electrolyte and
water transport, and the function of endothelial cells, platelets, mast cells, and macrophages …

Nitric oxide (NO) synthesis is markedly augmented in states of inflammation, largely due to
the expression of inducible nitric oxide synthase (iNOS). Although NO has anti-inflammatory …

Nitric oxide is a gaseous free radical synthesized via L-arginine oxidation by a family of nitric
oxide syntheses (NOS). Isomeric forms of NOS, representing at least three distinct and …

Nitric oxide (NO.) plays a central role in the physiology of the gastrointestinal tract and its
response to critical illness. Potential sources of NO. in the gut include: intrinsic intestinal …

There is growing evidence that endogenous nitric oxide (NO) regulates mucosal barrier
integrity under physiological conditions and counters the increase in mucosal permeability …

Nitric oxide is a ubiquitous molecule involved in a variety of biological processes. The
specific action of NO depends on its enzymatic sources namely neuronal nitric oxide …

Inflammation of the intestinal tract remains a very serious concern in the clinical setting.
Unfortunately, to date, the mechanisms underlying many inflammatory conditions such as …

Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it
also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis …