Effects of semaglutide versus dulaglutide on epicardial fat thickness in subjects with type 2 diabetes and obesity

G Iacobellis, AC Villasante Fricke - Journal of the Endocrine …, 2020 - academic.oup.com
Abstract Background and Aims Epicardial adipose tissue (EAT), the visceral fat depot of the
heart, is a modifiable cardio-metbolic risk factor and therapeutic target. Semaglutide and …

Liraglutide causes large and rapid epicardial fat reduction

G Iacobellis, M Mohseni, SD Bianco, PK Banga - Obesity, 2017 - Wiley Online Library
Objective Epicardial adipose tissue (EAT), the visceral fat depot of the heart, is a modifiable
cardiovascular risk factor and emerging therapeutic target. Liraglutide, an analog of …

Cardiovascular risk reduction throughout GLP-1 receptor agonist and SGLT2 inhibitor modulation of epicardial fat

G Iacobellis, MG Baroni - Journal of endocrinological investigation, 2022 - Springer
Epicardial adipose tissue is a novel cardiovascular risk factor. It plays a role in the
progression of coronary artery disease, heart failure and atrial fibrillation. Given its rapid …

Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate …

E Dozio, E Vianello, AE Malavazos, L Tacchini… - International journal of …, 2019 - Elsevier
Background Epicardial adipose tissue (EAT) is a risk factor for cardiovascular diseases.
Glucagon-like peptide 1 analogs (GLP-1A) may have beneficial cardiovascular effects and …

Efficacy of cardiometabolic drugs in reduction of epicardial adipose tissue: a systematic review and meta-analysis

VA Myasoedova, V Parisi, D Moschetta… - Cardiovascular …, 2023 - Springer
Background Epicardial adipose tissue (EAT) plays an important role in cardiometabolic risk.
EAT is a modifiable risk factor and could be a potential therapeutic target for drugs that …

Effect of SGLT2-inhibitors on epicardial adipose tissue: a meta-analysis

W Masson, A Lavalle-Cobo, JP Nogueira - Cells, 2021 - mdpi.com
(1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and
cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial …

Effect of semaglutide on cardiac structure and function in patients with obesity-related heart failure

SD Solomon, JW Ostrominski, X Wang, SJ Shah… - Journal of the American …, 2024 - jacc.org
Background Obesity is associated with adverse cardiac remodeling and is a key driver for
the development and progression of heart failure (HF). Once-weekly semaglutide (2.4 mg) …

Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of …

AE Malavazos, G Iacobellis, E Dozio… - European journal of …, 2023 - academic.oup.com
Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and
progression of coronary artery disease, atrial fibrillation, and heart failure. Microscopically …

Effect of sitagliptin on epicardial fat thickness in subjects with type 2 diabetes and obesity: a pilot study

MM Lima-Martínez, M Paoli, M Rodney, N Balladares… - Endocrine, 2016 - Springer
The aim of the study was to assess the effect of sitagliptin addition on the epicardial adipose
tissue (EAT) thickness in subjects with type 2 diabetes mellitus inadequately controlled on …

Visceral adipose tissue and residual cardiovascular risk: a pathological link and new therapeutic options

A Cesaro, G De Michele, F Fimiani, V Acerbo… - Frontiers in …, 2023 - frontiersin.org
Obesity is a heterogeneous disease that affects almost one-third of the global population. A
clear association has been established between obesity and cardiovascular disease (CVD) …