The ying and yang of STAT3 in human disease
The transcription factor signal transducer and activator of transcription 3 (STAT3) is a critical
regulator of multiple, diverse cellular processes. Heterozgyous, germline, loss-of-function …
regulator of multiple, diverse cellular processes. Heterozgyous, germline, loss-of-function …
Signal transducer and activator of transcription 3: a year in review
LR Forbes, J Milner, E Haddad - Current opinion in hematology, 2016 - journals.lww.com
The discovery of new gain-of-function mutations in STAT3, as well as new studies among
patients with loss-of-function mutations, expand the understanding of the pathophysiology of …
patients with loss-of-function mutations, expand the understanding of the pathophysiology of …
[HTML][HTML] Germline STAT3 gain-of-function mutations in primary immunodeficiency: impact on the cellular and clinical phenotype
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor
involved in regulation of immune cell activation and differentiation. Recent discoveries …
involved in regulation of immune cell activation and differentiation. Recent discoveries …
STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases
T Lorenzini, L Dotta, M Giacomelli… - Journal of Leucocyte …, 2017 - academic.oup.com
STAT proteins are a family of transcription factors that mediate cellular response to cytokines
and growth factors. Study of patients with familial susceptibility to pathogens and/or …
and growth factors. Study of patients with familial susceptibility to pathogens and/or …
STAT3 is a central regulator of lymphocyte differentiation and function
Highlights•Mutations in cytokine signalling pathways cause human primary
immunodeficiencies.•Mutations in STAT3 result in autosomal hyper-IgE syndrome (AD …
immunodeficiencies.•Mutations in STAT3 result in autosomal hyper-IgE syndrome (AD …
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
EM Haapaniemi, M Kaustio, HLM Rajala… - Blood, The Journal …, 2015 - ashpublications.org
The signal transducer and activator of transcription (STAT) family of transcription factors
orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and …
orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and …
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Germline loss-of-function mutations in the transcription factor signal transducer and activator
of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …
of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …
The ups and downs of STAT3 function: too much, too little and human immune dysregulation
The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …
Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity
S Jägle, M Heeg, S Grün, A Rensing-Ehl, ME Maccari… - Clinical …, 2020 - Elsevier
Germline STAT3 gain-of-function (GOF) mutations have been linked to poly-autoimmunity
and lymphoproliferation with variable expressivity and incomplete penetrance. Here we …
and lymphoproliferation with variable expressivity and incomplete penetrance. Here we …
The STAT5b pathway defect and autoimmunity
The signal transducer and activator of transcription (STAT) 5b is a universal transcription
factor that plays key biological roles in allergic diseases, immunodeficiencies …
factor that plays key biological roles in allergic diseases, immunodeficiencies …