Essential hypertension is associated with endothelial dysfunction, which is caused mainly by
the production of oxygen-free radicals that can destroy nitric oxide (NO), and impair its …

Essential hypertension is characterized by endothelial dysfunction due to reduced
availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals …

Essential hypertension is associated with impaired endothelium-dependent vasodilation
and is caused mainly by production of oxygen free radicals that can destroy nitric oxide …

A large body of evidence indicates that patients with essential hypertension are
characterized by endothelial dysfunction mediated by an impaired NO availability secondary …

Endothelial dysfunction is a common feature of hypertension, and it results from the
imbalanced release of endothelium-derived relaxing factors (EDRFs; in particular, nitric …

The endothelium is a favourite early target of cardiovascular risk factors and cardiovascular
diseases like hypertension. This key role of the endothelium results from its capacity to …

Background Vascular endothelial dysfunction may predict future atherosclerosis. Hence, an
antihypertensive agent that reverses endothelial dysfunction and lowers blood pressure …

Although the endothelium has a number of important functions, the term endothelial
dysfunction is commonly used to describe impairment in its vasodilatory capacity. It is …

Endothelium-derived nitric oxide is not only a potent vasodilator but also inhibits platelet
aggregation, smooth muscle cell proliferation, monocyte adhesion and adhesion molecule …

Endothelium can deeply influence vascular tone and structure. The main endothelium-
derived factor is nitric oxide (NO), which not only is a potent vasodilator but also inhibits …