Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway

V Ulivi, M Lenti, C Gentili, G Marcolongo… - Arthritis research & …, 2011 - Springer
Introduction The mono-and digalactosyldiacylglycerol (MGDG and DGDG) galactolipids
have been purified from the thermophilic blue-green alga Phormidium sp. ETS-05 that …

Monogalactosyldiacylglycerol anti-inflammatory activity on adult articular cartilage

M Lenti, C Gentili, A Pianezzi… - Natural Product …, 2009 - Taylor & Francis
The mono-and the digalactosyldiacylglycerol (MGDG and DGDG) galactolipids with a high
content of polyunsaturated fatty acids, mainly omega-3, have been purified from the …

Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a …

C Morin, PU Blier, S Fortin - Arthritis research & therapy, 2015 - Springer
Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the
joints and bones. Omega-3 (ω3) fatty acid supplementation has been associated with a …

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation

AKT Wann, J Mistry, EJ Blain, AT Michael-Titus… - Arthritis research & …, 2010 - Springer
Introduction In inflammatory joint disease, such as osteoarthritis (OA), there is an increased
level of proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines stimulate the …

Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of …

EV Tchetina, JA Di Battista, DJ Zukor, J Antoniou… - Arthritis research & …, 2007 - Springer
Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-β2
in cultured human osteoarthritic cartilage has been shown to be associated with decreased …

Glucosamine sulfate reduces prostaglandin E2 production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1

M Kapoor, F Mineau, H Fahmi, JP Pelletier… - The Journal of …, 2012 - jrheum.org
Objective. Glucosamine sulfate (GS) has been inferred to have a potential antiinflammatory
effect on osteoarthritis (OA). We investigated its effect on prostaglandin E2 (PGE2) in human …

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes

N Akhtar, TM Haqqi - Arthritis research & therapy, 2011 - Springer
Abstract Introduction Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green
tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene …

Suppression of human synovial cell proliferation by dihomo‐γ‐linolenic acid

DG Baker, KA Krakauer, G Tate… - … : Official Journal of …, 1989 - Wiley Online Library
Abstract Prostaglandin E1 (PGE1) and oils enriched in its precursor fatty acids suppress
inflammation and joint tissue injury in several animal models. Since synovial cell …

Increased expression of lipocalin-type prostaglandin D2synthase in osteoarthritic cartilage

N Zayed, X Li, N Chabane, M Benderdour… - Arthritis research & …, 2008 - Springer
Abstract Introduction Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of
PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic …

Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model

M Tsubosaka, S Kihara, S Hayashi… - Journal of …, 2020 - Wiley Online Library
Eicosapentanoic acid (EPA) is an antioxidant and omega‐3 polyunsaturated fatty acid that
reduces inflammatory cytokine production. Gelatin hydrogel can be used as a carrier of a …