Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

Activation of the PI3 kinase pathway can induce skeletal muscle hypertrophy, defined as an
increase in skeletal muscle mass. In mammals, skeletal muscle hypertrophy occurs as a …

Myostatin is a negative regulator of skeletal muscle growth and in fact acts as a potent
inducer of “cachectic-like” muscle wasting in mice. The mechanism of action of myostatin in …

Myostatin is a highly conserved negative regulator of skeletal muscle growth. Loss of
functional myostatin in cattle, mice, sheep, dogs, and humans results in increased muscle …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Myostatin deficiency leads to both an increased rate of protein synthesis and skeletal muscle
hypertrophy. However, the mechanisms involved in mediating these effects are not yet fully …

Myostatin, a member of the transforming growth factor-β superfamily, has been implicated in
the potent negative regulation of myogenesis in murine models. However, little is known …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

Myostatin, a member of the TGF-β family, has been identified as a master regulator of
embryonic myogenesis and early postnatal skeletal muscle growth. However, cumulative …

Myostatin, a member of the transforming growth factor β (TGF-β) superfamily, is a negative
regulator of skeletal muscle growth. We found that myostatin could activate c-Jun N-terminal …