Estrogen receptors have been found in normal and neoplastic gastrointestinal mucosa. The
aim of our study was to verify whether the content of cytosolic estrogen receptor in normal …

The protective role of estrogens in the colon carcinogenesis has been suggested for many
years and attributed mainly to estrogen receptor beta (ERβ). However, the direct effect of …

Menopausal hormone replacement therapy has been widely used to alleviate the symptoms
of menopause and to decrease the detrimental effects of ovarian hormone loss on bone …

Purpose Estrogen receptor β (ERβ) is abundantly expressed in colorectal tissue, but its role
in colorectal carcinogenesis remains elusive. Estrogen receptor coregulators, amplified in …

The characterization of estrogen receptor beta (ERβ) brought new insight into the
mechanisms underlying estrogen signaling. Estrogen induction of cell proliferation is a …

The concept that E2 exerts an effect on the gastrointestinal tract is not new and its actions on
intestinal mucosa have been investigated for at least three decades. An attempt to …

In recent years, several lines of epidemiologic, clinical and experimental evidences have
been reported showing that estrogen hormones may be involved in malignant colorectal …

Estrogen is involved in suppression of colorectal cancer development and exerts its function
via estrogen receptors α, β and their splicing variants. Whether the recently indentified ER-α …

The human ESR2 gene codes for estrogen receptor β1 and for multiple splice variants,
which are suggested to exert distinct functions in the cellular estrogen response. Given that …

Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …