The emerging and sustained resistance to antibiotics and the poor pipeline of new
antibacterials is creating a major health issue worldwide. Bacterial pathogens are …

Over the past decade, non-fermenting Gram-negative bacteria have emerged as important
opportunistic pathogens in the increasing population of patients who are …

Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

The use of combination antimicrobial therapy for bacteraemia caused by Gram-negative
bacilli is controversial. We did a meta-analysis of published studies to determine whether a …

Multidrug resistance in Gram-positive pathogens emerged as a major therapeutic challenge
over two decades ago. The worldwide spread of methicillin-resistant Staphylococcus aureus …

New drug development strategies are needed to combat antimicrobial resistance. The object
of this perspective is to highlight one such strategy: treating infections with sets of drugs …

This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The
article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for …

The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

tients with undefined bacterial infection;(b) to treat mixed bacterial infections, the
components of which may not have a common antibiotic susceptibility;(c) to prevent the …

The past decade has brought a significant rise in antimicrobial resistance, and the ESKAPE
pathogens have become a significant threat to public health. Three epidemiological features …