Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis
Y Zhu, X Huang, Z Deng, T Bai, B Gao, C Xu… - Journal of …, 2024 - Springer
Background Ulcerative colitis (UC) is defined by persistent inflammatory processes within
the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in …
the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in …
Engineered procyanidin-Fe nanoparticle alleviates intestinal inflammation through scavenging ROS and altering gut microbiome in colitis mice
Y Chang, X Wu, S Lu, J Du, Y Long, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory bowel disease
characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota …
characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota …
[HTML][HTML] Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease
Z Shi, X Li, J Chen, Z Dai, Y Zhu, T Wu, Q Liu, H Qin… - Bioactive Materials, 2024 - Elsevier
Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks
and microbial imbalance play critical roles in the development of inflammatory bowel …
and microbial imbalance play critical roles in the development of inflammatory bowel …
A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease
F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …
Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management
Z Deng, W Ma, C Ding, C Wei, B Gao, Y Zhu, Y Zhang… - Nano Today, 2023 - Elsevier
Intestinal inflammation, such as ulcerative colitis (UC), is a condition in which there is
chronic or recurring inflammation of the gastrointestinal tract. Designing safe, effective, and …
chronic or recurring inflammation of the gastrointestinal tract. Designing safe, effective, and …
Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis
H Zhao, Y Du, L Liu, Y Du, K Cui, P Yu, L Li… - Journal of Materials …, 2022 - pubs.rsc.org
Probiotic-based therapy for ulcerative colitis (UC) is a novel and promising approach that
has gained much popularity in recent years. However, probiotics may be easily captured …
has gained much popularity in recent years. However, probiotics may be easily captured …
2D Nanozymes Modulate Gut Microbiota and T‐Cell Differentiation for Inflammatory Bowel Disease Management
K Jiang, X Cao, H Wu, Y Xu, L Liu… - Advanced …, 2024 - Wiley Online Library
Intestinal commensal microbiota dysbiosis and immune dysfunction are significant
exacerbating factors in inflammatory bowel disease (IBD). To address these problems …
exacerbating factors in inflammatory bowel disease (IBD). To address these problems …
Restoration of dysregulated intestinal barrier and inflammatory regulation through synergistically ameliorating hypoxia and scavenging reactive oxygen species using …
Y Zhang, H Lei, P Wang, Q Zhou, J Yu, X Leng… - Biomaterials …, 2023 - spj.science.org
Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play
pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS …
pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS …
Multifunctional nanozyme hydrogel with mucosal healing activity for single-dose ulcerative colitis therapy
Nanozymes are nanomaterials with enzyme-like activities, which have been developed for
inflammatory disease therapy by reactive oxygen species (ROS) scavenging. The …
inflammatory disease therapy by reactive oxygen species (ROS) scavenging. The …
Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …