Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis

Y Zhu, X Huang, Z Deng, T Bai, B Gao, C Xu… - Journal of …, 2024 - Springer
Background Ulcerative colitis (UC) is defined by persistent inflammatory processes within
the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in …

Engineered procyanidin-Fe nanoparticle alleviates intestinal inflammation through scavenging ROS and altering gut microbiome in colitis mice

Y Chang, X Wu, S Lu, J Du, Y Long, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory bowel disease
characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota …

[HTML][HTML] Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Z Shi, X Li, J Chen, Z Dai, Y Zhu, T Wu, Q Liu, H Qin… - Bioactive Materials, 2024 - Elsevier
Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks
and microbial imbalance play critical roles in the development of inflammatory bowel …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management

Z Deng, W Ma, C Ding, C Wei, B Gao, Y Zhu, Y Zhang… - Nano Today, 2023 - Elsevier
Intestinal inflammation, such as ulcerative colitis (UC), is a condition in which there is
chronic or recurring inflammation of the gastrointestinal tract. Designing safe, effective, and …

Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis

H Zhao, Y Du, L Liu, Y Du, K Cui, P Yu, L Li… - Journal of Materials …, 2022 - pubs.rsc.org
Probiotic-based therapy for ulcerative colitis (UC) is a novel and promising approach that
has gained much popularity in recent years. However, probiotics may be easily captured …

2D Nanozymes Modulate Gut Microbiota and T‐Cell Differentiation for Inflammatory Bowel Disease Management

K Jiang, X Cao, H Wu, Y Xu, L Liu… - Advanced …, 2024 - Wiley Online Library
Intestinal commensal microbiota dysbiosis and immune dysfunction are significant
exacerbating factors in inflammatory bowel disease (IBD). To address these problems …

Restoration of dysregulated intestinal barrier and inflammatory regulation through synergistically ameliorating hypoxia and scavenging reactive oxygen species using …

Y Zhang, H Lei, P Wang, Q Zhou, J Yu, X Leng… - Biomaterials …, 2023 - spj.science.org
Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play
pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS …

Multifunctional nanozyme hydrogel with mucosal healing activity for single-dose ulcerative colitis therapy

C Cheng, Y Cheng, S Zhao, Q Wang, S Li… - Bioconjugate …, 2021 - ACS Publications
Nanozymes are nanomaterials with enzyme-like activities, which have been developed for
inflammatory disease therapy by reactive oxygen species (ROS) scavenging. The …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …