Iron plays an important role in mammalian physiological processes. It is a critical component
for the function of many proteins, including enzymes that require heme and iron-sulfur …

Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual
bacterial species, iron is indispensable for living organisms. However, free iron is toxic …

Iron is an essential metal in the biologic processes of many organisms, particularly those in
an oxygen-rich environment. The primary role of iron in mammals is to provide a binding site …

Iron is essential for life, because it is indispensable for several biological reactions such as
oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since …

Background Iron is vital for almost all living organisms by participating in a wide range of
metabolic processes. However, iron concentration in body tissues must be tightly regulated …

Biological iron is necessary for vital functions and also potentially toxic to the organisms.
This dual effect raised the interest of many investigators to study the mechanisms controlling …

Although iron is a relatively abundant element in the universe, it is estimated that more than
2 billion people worldwide suffer from iron deficiency anemia. Iron deficiency results in …

As iron is essential for fundamental vital activities, iron deprivation threatens cell survival,
thus making iron deficiency in humans a public health problem throughout the world and …

The last ten years have seen exponential progress in both the identification and
understanding of the mechanisms of disease in disorders of iron metabolism. A new field of …

Iron is an essential micronutrient for oxygen transport, cellular energy metabolism, and many
enzymatic reactions. Complex physiological processes have evolved for iron acquisition to …