Biomarkers of inflammation and the etiology of sepsis

I Grondman, A Pirvu, A Riza, M Ioana… - Biochemical Society …, 2020 - portlandpress.com
Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

Biomarkers for sepsis: what is and what might be?

BM Biron, A Ayala, JL Lomas-Neira - Biomarker insights, 2015 - journals.sagepub.com
Every year numerous individuals develop the morbid condition of sepsis. Therefore, novel
biomarkers that might better inform clinicians treating such patients are sorely needed …

Sepsis: network pathophysiology and implications for early diagnosis

J Arora, AA Mendelson… - American Journal of …, 2023 - journals.physiology.org
Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

Biomarkers of sepsis

JD Faix - Critical reviews in clinical laboratory sciences, 2013 - Taylor & Francis
Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

The pathogenesis of sepsis

DJ Stearns-Kurosawa, MF Osuchowski… - Annual review of …, 2011 - annualreviews.org
Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges

Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Biomarkers of sepsis

JC Marshall, K Reinhart - Critical care medicine, 2009 - journals.lww.com
Background: A complex network of biological mediators underlies the clinical syndrome of
sepsis. The nonspecific physiologic criteria of sepsis syndrome or the systemic inflammatory …

New approaches to sepsis: molecular diagnostics and biomarkers

K Reinhart, M Bauer, NC Riedemann… - Clinical microbiology …, 2012 - Am Soc Microbiol
Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Pathophysiologic mechanisms in septic shock

EG King, GJ Bauzá, JR Mella, DG Remick - Laboratory investigation, 2014 - nature.com
The systemic inflammatory response that occurs in the septic patient as a result of an
infectious insult affects multiple organs and systems, causing numerous physiological …