Neurons of the peripheral nervous system detect changes in temperature through activation
of specialised ion channels. Members of the transient receptor potential family TRPM8 and …

Recent electrophysiological studies of cultured dorsal root and trigeminal ganglion neurons
have suggested that multiple ionic mechanisms underlie the peripheral detection of cold …

Different classes of ion channels have been implicated in sensing cold temperatures at
mammalian thermoreceptor nerve endings. A major candidate is TRPM8, a non‐selective …

Detection and adaptation to cold temperature is crucial to survival. Cold sensing in the
innocuous range of cold (> 10–15° C) in the mammalian peripheral nervous system is …

TRPM8 and TRPA1, members of the transient receptor potential (TRP) channel family, are
candidates for cooling-activated receptors. It is accepted that TRPM8 responds to moderate …

The transient receptor potential (TRP) superfamily of cation channels contains four
temperature‐sensitive channels, named TRPV1–4, that are activated by heat stimuli from …

Several mechanisms have been implicated in underlying the perception of cold, most
notably the activation of TRPM8 and TRPA1. We have used ratiometric calcium imaging to …

Cold sensing in mammals is heterogeneous and more than one type of receptor molecule is
likely to be involved in the transduction process. Most features of innocuous cold receptors …

ThermoTRPs, a subset of the Transient Receptor Potential (TRP) family of cation channels,
have been implicated in sensing temperature. TRPM8 and TRPA1 are both activated by …

Cold sensing in mammals is not completely understood, although significant progress has
been made recently with the cloning of two cold‐activated ion channels, TRPM8 and …