Alternative Splicing and Extensive RNA Editing of Human TPH2 Transcripts
M Grohmann, P Hammer, M Walther, N Paulmann… - PloS one, 2010 - journals.plos.org
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has
been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is …
been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is …
A functional alternative splicing mutation in human tryptophan hydroxylase-2
The brain serotonergic system has an essential role in the physiological functions of the
central nervous system and dysregulation of serotonin (5-HT) homeostasis has been …
central nervous system and dysregulation of serotonin (5-HT) homeostasis has been …
Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
L Gutknecht, C Kriegebaum, J Waider, A Schmitt… - European …, 2009 - Elsevier
Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …
been implicated in various neuropsychiatric disorders, although the differential expression …
Functional characterization of the human TPH2 5′ regulatory region: untranslated region and polymorphisms modulate gene expression in vitro
GL Chen, EJ Vallender, GM Miller - Human genetics, 2008 - Springer
Abstract Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible
for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a …
for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a …
Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: Focus on animal models
EA Kulikova, AV Kulikov - Expert Opinion on Therapeutic Targets, 2019 - Taylor & Francis
ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …
Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland
PD Patel, C Pontrello, S Burke - Biological psychiatry, 2004 - Elsevier
BACKGROUND: Regulation of raphe serotonergic cells is fundamental to the prevailing
hypothesis of major depression pathophysiology. Tryptophan hydroxylase (TPH) is the rate …
hypothesis of major depression pathophysiology. Tryptophan hydroxylase (TPH) is the rate …
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
K Nakamura, Y Sugawara, K Sawabe… - Journal of …, 2006 - Soc Neuroscience
Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Functional properties of missense variants of human tryptophan hydroxylase 2
JA McKinney, B Turel, I Winge, PM Knappskog… - Human …, 2009 - Wiley Online Library
Abstract Tryptophan hydroxylase 2 (TPH2) catalyzes the rate‐limiting step in serotonin
biosynthesis in the nervous system. Several variants of human TPH2 have been reported to …
biosynthesis in the nervous system. Several variants of human TPH2 have been reported to …
Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
KV Savelieva, S Zhao, VM Pogorelov, I Rajan, Q Yang… - PloS one, 2008 - journals.plos.org
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression
F Haghighi, H Bach-Mizrachi, YY Huang… - Molecular …, 2008 - nature.com
Impaired brain serotonin neurotransmission is a potential component of the diathesis of
major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic …
major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic …