The autooxidation of polyene antibiotics has been reported1,2) and is thought to be a possible
mech- anism of inactivation3). Th Page 1 753 VOL. XXXVIII NO. 6 THE JOURNAL OF …

We have previously studied the autoxidation of the polyene antibiotic amphotericin B (AB). In
this paper we describe the dependence of the kinetics of autoxidation on the aggregation …

Both example compounds obtained in syntheses I and II exhibited electronic absorption
maxima of the same wavelength as amphotericin B itself at J,= 363, 382 and 406 nm …

Four antioxidants, propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and d-
α-tocopherol acid succinate were found to stabilize amphotericin B and to prolong its …

The antifungal effects of amphotericin B are believed to be due to two possibly interrelated
mechanisms: an increase in permeation by binding to sterols in cellular membranes and a …

Circular dichroism and absorption and light scattering have been used to study the effect of
ethyl alcohol on an aqueous solution of Amphotericin B (“Fungizone”), which is an antifungal …

Fig. 4. Computergenerated perspective drawing of naphterpin. data proved the relations
among C-14, C-15, C-17 (25.6 ppm) and C-18 as shown in Fig. 1. The methine proton 9-H …

Proteins and lipids maybe important targets of oxidation and this may alter their functions.
We evaluated whether ceftazidima (CAZ), piperacillin (PIP), chloramphenicol (CMP), and …

The ability of the widely used antibiotic benzylpenicillin G to undergo a peroxidatic oxidation
to produce free radical species has been investigated using conventional …

During the period 1967 and 1980 the structures of 60 polyether antibiotics were elucidated
by the application of physiochemical techniques, as described in Chapters 3 to 6 of this …