The extracellular matrix (ECM) is a complex three-dimensional network of proteins
surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and …

Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial
fibroblasts. However, whether these events are somehow connected is poorly understood. In …

The glomerulus contains unique cellular and extracellular matrix (ECM) components, which
are required for intact barrier function. Studies of the cellular components have helped to …

Glomerular disease often features altered histologic patterns of extracellular matrix (ECM).
Despite this, the potential complexities of the glomerular ECM in both health and disease …

The glomerular basement membrane (GBM) is a specialized extracellular matrix (ECM)
compartment within the glomerulus that contains tissue-restricted isoforms of collagen IV …

Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

Fibrosis is the most common pathophysiological manifestation of Chronic Kidney Disease
(CKD). It is defined as excessive deposition of extracellular matrix (ECM) proteins …

Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Renal fibroblasts are thought to play a major role in the development of renal fibrosis (RF).
The mechanisms leading to this renal alteration remain poorly understood. We performed …