Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …

Here we visualize new aspects of the dynamics of endocytotic clathrin-coated pits and
vesicles in mammalian cells by using a fusion protein consisting of green fluorescent protein …

Receptor-mediated endocytosis of ligands, such as transferrin and LDL, is suppressed when
clathrin synthesis is blocked by RNA interference in HeLa cells. We have found that domains …

Our understanding of the clathrin-dependent endocytic pathway owes much to new
visualization techniques. Budding coated pits and clathrin-coated structures are transient …

Clathrin lattices at the plasma membrane coat both invaginated and flat regions forming
clathrin-coated pits and clathrin plaques, respectively. The function and regulation of clathrin …

Clathrin-coated structures are involved in the first steps of membrane vesiculation which
lead to receptor sorting and directed traffic. This review focuses on our current …

Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small
regions of the cell surface into spherical vesicles. The key mechanistic question of how coat …

Clathrin mediated endocytosis (CME) is the main route of receptor internalization in
mammalian cells and this well conserved mechanism has been intensively studied for over …

Flat clathrin lattices or 'plaques' are commonly believed to be the precursors to clathrin‐
coated buds and vesicles. The sequence of steps carrying the flat hexagonal lattice into a …

Although essential for many cellular processes, the sequence of structural and molecular
events during clathrin-mediated endocytosis remains elusive. While it was long believed that …