[HTML][HTML] Modified Qing'e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway

S Zhu, W Qin, T Liu, T Liu, H Ma, C Hu, X Yue… - Frontiers in …, 2022 - frontiersin.org
Exposure to ultraviolet (UV) light triggers the rapid generation and accumulation of reactive
oxygen species (ROS) in skin cells, which increases oxidative stress damage and leads to …

[HTML][HTML] The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

S Tao, R Justiniano, DD Zhang, GT Wondrak - Redox Biology, 2013 - Elsevier
Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis
and photoaging, and an urgent need exists for improved strategies for skin photoprotection …

Activation of Nrf2 reduces UVA-mediated MMP-1 upregulation via MAPK/AP-1 signaling cascades: the photoprotective effects of sulforaphane and hispidulin

A Chaiprasongsuk, J Lohakul, K Soontrapa… - … of Pharmacology and …, 2017 - ASPET
UVA irradiation plays a role in premature aging of the skin through triggering oxidative stress-
associated stimulation of matrix metalloproteinase-1 (MMP-1) responsible for collagen …

[HTML][HTML] Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis

A Hirota, Y Kawachi, K Itoh, Y Nakamura, X Xu… - Journal of investigative …, 2005 - Elsevier
Ultraviolet (UV) radiation is one of the most important environmental factors involved in the
pathogenesis of skin aging and cancer. Many harmful effects of UV radiation are associated …

Nrf2-mediated protection against UVA radiation in human skin keratinocytes

F Tian, F Zhang, X Lai, L Wang, L Yang, X Wang… - Bioscience …, 2011 - jstage.jst.go.jp
Summary Ultraviolet A (UVA, 320-400 nm) radiation is an oxidizing agent that causes
significant damage to cellular components and that leads to photoaging and cancer. It …

Thymus vulgaris alleviates UVB irradiation induced skin damage via inhibition of MAPK/AP‐1 and activation of Nrf2‐ARE antioxidant system

Z Sun, SY Park, E Hwang, M Zhang… - Journal of cellular …, 2017 - Wiley Online Library
Solar ultraviolet (UV) radiation‐induced reactive oxidative species is mainly responsible for
the development of photoageing. Rosmarinic acid was one of the main bioactive …

Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and …

K Kleszczyński, IMA Ernst, AE Wagner, N Kruse… - Pharmacological …, 2013 - Elsevier
Chronic UVR-exposure may impair the stress response and antioxidant defense
mechanisms of human skin. The transcription factor nuclear factor erythroid-2 related factor …

Proteins involved in the antioxidant and inflammatory response in rutin-treated human skin fibroblasts exposed to UVA or UVB irradiation

A Gęgotek, P Domingues, E Skrzydlewska - Journal of Dermatological …, 2018 - Elsevier
Background Rutin, due to its polyphenolic structure, has antioxidant properties and can be
used as a cytoprotective compound against UV-induced effects on skin cells. Objective The …

[HTML][HTML] Protease-activated receptor 2 induces ROS-mediated inflammation through Akt-mediated NF-κB and FoxO6 modulation during skin photoaging

EJ Bang, DH Kim, HY Chung - Redox Biology, 2021 - Elsevier
Long-term exposure to ultraviolet irradiation to skin leads to deleterious intracellular effects,
including reactive oxygen species (ROS) production and inflammatory responses, causing …

Establishment of Nrf2-deficient HaCaT and immortalized primary human foreskin keratinocytes and characterization of their responses to ROS-induced cytotoxicity

M Choi, M Park, S Lee, JW Lee, WJ Choi, C Lee - Toxicology in Vitro, 2019 - Elsevier
Abstract Nuclear factor erythroid 2-like 2 (Nrf2) is a key transcription factor responsible for
the induction of cytoprotective genes when a cell is exposed to reactive oxygen species …