[HTML][HTML] Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling
S Jeayeng, A Wongkajornsilp, AT Slominski… - Free Radical Biology …, 2017 - Elsevier
Responses of melanocytes (MC) to ultraviolet (UV) irradiation can be influenced by their
neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine …
neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine …
Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling …
Excessive exposure of skin to UV radiation triggers the generation of oxidative stress,
inflammation, immunosuppression, apoptosis, matrix-metalloproteases production, and DNA …
inflammation, immunosuppression, apoptosis, matrix-metalloproteases production, and DNA …
Cytoprotective effect of ascorbic acid and rutin against oxidative changes in the proteome of skin fibroblasts cultured in a three-dimensional system
A Gęgotek, I Jarocka-Karpowicz, E Skrzydlewska - Nutrients, 2020 - mdpi.com
The combination of ascorbic acid and rutin, commonly used in oral preparations for their
antioxidant and anti-inflammatory properties, can also be used to protect skin cells from the …
antioxidant and anti-inflammatory properties, can also be used to protect skin cells from the …
Nrf2 deficiency causes lipid oxidation, inflammation, and matrix-protease expression in DHA-supplemented and UVA-irradiated skin fibroblasts
F Gruber, CM Ornelas, S Karner, MS Narzt… - Free Radical Biology …, 2015 - Elsevier
Fish oil rich in docosahexaenoic acid (DHA) has beneficial effects on human health. Omega-
3 polyunsaturated fatty acids are precursors of eicosanoids and docosanoids, signaling …
3 polyunsaturated fatty acids are precursors of eicosanoids and docosanoids, signaling …
NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
The skin barrier and its endogenous protective mechanisms cope daily with exogenous
stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin …
stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin …
[HTML][HTML] Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo
M Durchdewald, TA Beyer, DA Johnson… - Journal of investigative …, 2007 - Elsevier
The NF-E2-related factor 2 (Nrf2) transcription factor is a potent inducer of cytoprotective
genes, which encode–among others–enzymes that detoxify reactive oxygen species (ROS) …
genes, which encode–among others–enzymes that detoxify reactive oxygen species (ROS) …
[HTML][HTML] Pathogenic and therapeutic role for NRF2 signaling in ultraviolet light–induced skin pigmentation
Mottled skin pigmentation and solar lentigines from chronic photodamage with aging involve
complex interactions between keratinocytes and melanocytes. However, the precise …
complex interactions between keratinocytes and melanocytes. However, the precise …
Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway
S Gao, K Guo, Y Chen, J Zhao, R Jing… - Frontiers in …, 2021 - frontiersin.org
Objective: Exposure to ultraviolet B (UVB) can cause skin damage through oxidative stress,
DNA damage, and apoptosis. Keratinocyte growth factor (KGF) has been shown to reduce …
DNA damage, and apoptosis. Keratinocyte growth factor (KGF) has been shown to reduce …
Limonene protects human skin keratinocytes against UVB‐induced photodamage and photoaging by activating the Nrf2‐dependent antioxidant defense system
Long term exposure to solar ultraviolet B (UVB) radiation is one of the primary factors of
premature skin aging and is referred to as photoaging. Also, mammalian skin exposed to …
premature skin aging and is referred to as photoaging. Also, mammalian skin exposed to …
Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation
H Ikehata, M Yamamoto - Toxicology and Applied Pharmacology, 2018 - Elsevier
Abstract The KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (NF-E2-related factor 2)
system controls the biochemical defense activity against agents toxic to mammals and …
system controls the biochemical defense activity against agents toxic to mammals and …