Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic
monoamine serotonin (5-hydroxytryptamine, 5-HT). Two existing TPH isoforms are …

Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …

Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …

Abstract Serotonin (5‐HT) is a neurotransmitter involved in many aspects of the neuronal
function. The synthesis of 5‐HT is initiated by the hydroxylation of tryptophan, catalyzed by …

Serotonin (5-hydroxytryptophan, 5-HT) is a neurotransmitter synthesized in the raphe nuclei
of the brain stem and involved in the central control of food intake, sleep, and mood …

Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has
been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is …

Since its identification, 75 years ago, the monoamine serotonin (5-HT) has attracted
considerable attention toward its role as a neurotransmitter in the central nervous system …

Depression and anxiety are among the leading causes of societal burden. Abnormalities in
5-hydroxytryptamine (5-HT; serotonin) neurotransmission are known to be associated with …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …