Investigation of exposure biomarkers in human plasma following differing levels of tobacco-specific N-nitrosamines and nicotine in cigarette smoke

J Zhang, X Liu, B Shi, Z Yang, Y Luo, T Xu, D Liu… - Environmental …, 2022 - Elsevier
Tobacco-specific N-nitrosamines (TSNAs) are strong carcinogens widely found in tobacco
products, environmental tobacco smoke, lake, and wastewater. The main objective of this …

Assessment of tobacco specific nitrosamines (TSNAs) in oral fluid as biomarkers of cancer risk: A population-based study

R Pérez-Ortuño, JM Martínez-Sánchez, M Fu… - Environmental …, 2016 - Elsevier
Background Smoke-free laws are expected to reduce smoking habits and exposure to
secondhand smoke. The objective of this study was the measurement of tobacco specific …

Thirdhand exposures to tobacco-specific nitrosamines through inhalation, dust ingestion, dermal uptake, and epidermal chemistry

X Tang, N Benowitz, L Gundel, B Hang… - … science & technology, 2022 - ACS Publications
Tobacco-specific nitrosamines (TSNAs) are emitted during smoking and form indoors by
nitrosation of nicotine. Two of them, N′-nitrosonornicotine (NNN) and 4 …

Urine concentrations of a tobacco-specific nitrosamine carcinogen in the US population from secondhand smoke exposure

JT Bernert, JL Pirkle, Y Xia, RB Jain, DL Ashley… - … , biomarkers & prevention, 2010 - AACR
Background: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and its reduction product in the body, 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC–MS/MS: evidence of linkage to methylated DNA lesions

CW Hu, YW Hsu, JL Chen, LM Tam, MR Chao - Archives of toxicology, 2014 - Springer
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its urinary metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are the most investigated carcinogenic …

Tobacco product use patterns, and nicotine and tobacco-specific nitrosamine exposure: NHANES 1999–2012

K Choi, M Sabado, S El-Toukhy, E Vogtmann… - … Biomarkers & Prevention, 2017 - AACR
Background: Few studies have examined differences in product consumption patterns and
nicotine and tobacco-specific nitrosamines (TSNA) exposure between single versus dual …

Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke

G Radwan, SS Hecht, SG Carmella… - Nicotine & Tobacco …, 2012 - academic.oup.com
Introduction: The causal relationship between tobacco smoking and a variety of cancers is
attributable to the carcinogens that smokers inhale, including tobacco-specific nitrosamines …

Tobacco-Specific Nitrosamines and Their Pyridine-N-glucuronides in the Urine of Smokers and Smokeless Tobacco Users

I Stepanov, SS Hecht - Cancer Epidemiology Biomarkers & Prevention, 2005 - AACR
Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in
people who use tobacco products. Whereas the uptake of one tobacco-specific nitrosamine …

Nicotine and toxicant exposure among US smokeless tobacco users: results from 1999 to 2012 National Health and Nutrition Examination Survey Data

BL Rostron, CM Chang, DM van Bemmel, Y Xia… - … Biomarkers & Prevention, 2015 - AACR
Background: It has been suggested that smokeless tobacco users have high nicotine and
toxicant exposure, but studies with nationally representative data have been limited …

Tobacco-specific nitrosamines in the tobacco and mainstream smoke of US commercial cigarettes

SH Edwards, LM Rossiter, KM Taylor… - Chemical research in …, 2017 - ACS Publications
Tobacco-specific nitrosamines (TSNAs) are N-nitroso-derivatives of pyridine-alkaloids (eg,
nicotine) present in tobacco and cigarette smoke. Two TSNAs, N′-nitrosonornicotine (NNN) …