Being a good anti-tumor drug, camptothecin (CPT) is a kind of modified monoterpene indole
alkaloid firstly isolated from the deciduous Chinese happy tree with rapidly increasing …

Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …

Camptothecin (CPT) is an antitumor alkaloid first isolated from Chinese tree Camptotheca
acuminata Decaisne (Nyssaceae). Several attempts have been made to improve CPT …

Camptotheca acuminata produces camptothecin (CPT), a monoterpene indole alkaloid
(MIA) that is widely used in the treatment of lung, colorectal, cervical, and ovarian cancers …

Camptothecin (CPT) belongs to a group of monoterpenoidindole alkaloids (TIAs) and its
derivatives such as irinothecan and topothecan have been widely used worldwide for the …

Catharanthus roseus is a perennial herb of the Apocynaceae family, from which about 200
kinds of alkaloids have been characterized. Most alkaloids from C. roseus are terpenoid …

Camptothecin (CPT) has powerful biological activities and its analogs, irinothecan and
topothecan, are effective anti-cancer drugs for clinical therapy. Camptothecin was first …

Camptothecin is a monoterpenoid indole alkaloid that exhibits anti-tumor activity. In
Ophiorrhiza pumila, production of camptothecin and its related alkaloids was high in the …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …