[PDF][PDF] The proteogenomic landscape of curable prostate cancer
DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
[PDF][PDF] Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
S Varambally, J Yu, B Laxman, DR Rhodes, R Mehra… - Cancer cell, 2005 - cell.com
Molecular profiling of cancer at the transcript level has become routine. Large-scale analysis
of proteomic alterations during cancer progression has been a more daunting task. Here, we …
of proteomic alterations during cancer progression has been a more daunting task. Here, we …
Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression
L Latonen, E Afyounian, A Jylhä, J Nättinen… - Nature …, 2018 - nature.com
To understand functional consequences of genetic and transcriptional aberrations in
prostate cancer, the proteomic changes during disease formation and progression need to …
prostate cancer, the proteomic changes during disease formation and progression need to …
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
A Kumar, TA White, AP MacKenzie… - Proceedings of the …, 2011 - National Acad Sciences
To catalog protein-altering mutations that may drive the development of prostate cancers
and their progression to metastatic disease systematically, we performed whole-exome …
and their progression to metastatic disease systematically, we performed whole-exome …
Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer
Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
[PDF][PDF] Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories
Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …
impediments to the adoption of precision medicine in patients with prostate cancer. To …
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study
Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
The long tail of oncogenic drivers in prostate cancer
Comprehensive genomic characterization of prostate cancer has identified recurrent
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …
Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
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