Natural products show diverse mechanisms of action against Clostridium difficile
N Roshan, TV Riley, DR Knight, JH Steer… - Journal of applied …, 2019 - academic.oup.com
Aims To investigate the mechanisms of action of natural products with bactericidal
(cinnamon root powder, peppermint oil, trans‐cinnamaldehyde, menthol and zingerone) or …
(cinnamon root powder, peppermint oil, trans‐cinnamaldehyde, menthol and zingerone) or …
Antimicrobial activity of natural products against Clostridium difficile in vitro
N Roshan, TV Riley, KA Hammer - Journal of applied …, 2017 - academic.oup.com
Aims To investigate the antimicrobial activity of various natural products against Clostridium
difficile in vitro. Methods and Results The antibacterial activity of 20 natural products was …
difficile in vitro. Methods and Results The antibacterial activity of 20 natural products was …
Prospects for flavonoid and related phytochemicals as nature‐inspired treatments for Clostridium difficile infection
Aims There is a need for novel treatments for Clostridium difficile infection (CDI).
Antibacterial flavonoids are part of a large family of polyphenol phytochemicals with a long …
Antibacterial flavonoids are part of a large family of polyphenol phytochemicals with a long …
Effects of natural products on several stages of the spore cycle of Clostridium difficile in vitro
N Roshan, TV Riley, KA Hammer - Journal of applied …, 2018 - academic.oup.com
Aims To investigate the effect of natural products on the spore cycle of Clostridium difficile in
vitro. Methods and Results Twenty‐two natural products were investigated using four C …
vitro. Methods and Results Twenty‐two natural products were investigated using four C …
Effect of natural products on the production and activity of Clostridium difficile toxins in vitro
Clostridium difficile infection is a toxin-mediated disease of the colon. C. difficile virulence is
primarily attributed to the production of toxin A and toxin B; thus this study was aimed to …
primarily attributed to the production of toxin A and toxin B; thus this study was aimed to …
Carvacrol and trans-Cinnamaldehyde Reduce Clostridium difficile Toxin Production and Cytotoxicity in Vitro
Clostridium difficile is a nosocomial pathogen that causes a serious toxin-mediated enteric
disease in humans. Reducing C. difficile toxin production could significantly minimize its …
disease in humans. Reducing C. difficile toxin production could significantly minimize its …
Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo
Clostridioides difficile infection is a global health threat and remains the primary cause of
hospital-acquired infections worldwide. The burgeoning incidence and severity of infections …
hospital-acquired infections worldwide. The burgeoning incidence and severity of infections …
A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile
DS Katzianer, T Yano, H Rubin, J Zhu - International journal of antimicrobial …, 2014 - Elsevier
Clostridium difficile, a highly drug-resistant Gram-positive, spore-forming bacterium, remains
a leading cause of hospital-acquired diarrhoea and antibiotic-associated colitis. Clinically …
a leading cause of hospital-acquired diarrhoea and antibiotic-associated colitis. Clinically …
Progress in the discovery of treatments for C. difficile infection: a clinical and medicinal chemistry review
LS Tsutsumi, YB Owusu, JG Hurdle… - Current topics in …, 2014 - ingentaconnect.com
Clostridium difficile is an anaerobic, Gram-positive pathogen that causes C. difficile infection,
which results in significant morbidity and mortality. The incidence of C. difficile infection in …
which results in significant morbidity and mortality. The incidence of C. difficile infection in …
Carvacrol reduces Clostridium difficile sporulation and spore outgrowth in vitro
S Mooyottu, G Flock… - Journal of Medical …, 2017 - microbiologyresearch.org
Purpose. Clostridium difficile is an anaerobic spore-forming pathogen that causes a serious
toxin-mediated enteric disease in humans. Therapeutic agents that are capable of reducing …
toxin-mediated enteric disease in humans. Therapeutic agents that are capable of reducing …