Natural products show diverse mechanisms of action against Clostridium difficile

N Roshan, TV Riley, DR Knight, JH Steer… - Journal of applied …, 2019 - academic.oup.com
Aims To investigate the mechanisms of action of natural products with bactericidal
(cinnamon root powder, peppermint oil, trans‐cinnamaldehyde, menthol and zingerone) or …

Antimicrobial activity of natural products against Clostridium difficile in vitro

N Roshan, TV Riley, KA Hammer - Journal of applied …, 2017 - academic.oup.com
Aims To investigate the antimicrobial activity of various natural products against Clostridium
difficile in vitro. Methods and Results The antibacterial activity of 20 natural products was …

Prospects for flavonoid and related phytochemicals as nature‐inspired treatments for Clostridium difficile infection

X Wu, MZ Alam, L Feng, LS Tsutsumi… - Journal of applied …, 2014 - academic.oup.com
Aims There is a need for novel treatments for Clostridium difficile infection (CDI).
Antibacterial flavonoids are part of a large family of polyphenol phytochemicals with a long …

Effects of natural products on several stages of the spore cycle of Clostridium difficile in vitro

N Roshan, TV Riley, KA Hammer - Journal of applied …, 2018 - academic.oup.com
Aims To investigate the effect of natural products on the spore cycle of Clostridium difficile in
vitro. Methods and Results Twenty‐two natural products were investigated using four C …

Effect of natural products on the production and activity of Clostridium difficile toxins in vitro

N Roshan, TV Riley, DR Knight, KA Hammer - Scientific Reports, 2018 - nature.com
Clostridium difficile infection is a toxin-mediated disease of the colon. C. difficile virulence is
primarily attributed to the production of toxin A and toxin B; thus this study was aimed to …

Carvacrol and trans-Cinnamaldehyde Reduce Clostridium difficile Toxin Production and Cytotoxicity in Vitro

S Mooyottu, A Kollanoor-Johny, G Flock… - International journal of …, 2014 - mdpi.com
Clostridium difficile is a nosocomial pathogen that causes a serious toxin-mediated enteric
disease in humans. Reducing C. difficile toxin production could significantly minimize its …

Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo

R Pal, MN Seleem - Plos one, 2022 - journals.plos.org
Clostridioides difficile infection is a global health threat and remains the primary cause of
hospital-acquired infections worldwide. The burgeoning incidence and severity of infections …

A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile

DS Katzianer, T Yano, H Rubin, J Zhu - International journal of antimicrobial …, 2014 - Elsevier
Clostridium difficile, a highly drug-resistant Gram-positive, spore-forming bacterium, remains
a leading cause of hospital-acquired diarrhoea and antibiotic-associated colitis. Clinically …

Progress in the discovery of treatments for C. difficile infection: a clinical and medicinal chemistry review

LS Tsutsumi, YB Owusu, JG Hurdle… - Current topics in …, 2014 - ingentaconnect.com
Clostridium difficile is an anaerobic, Gram-positive pathogen that causes C. difficile infection,
which results in significant morbidity and mortality. The incidence of C. difficile infection in …

Carvacrol reduces Clostridium difficile sporulation and spore outgrowth in vitro

S Mooyottu, G Flock… - Journal of Medical …, 2017 - microbiologyresearch.org
Purpose. Clostridium difficile is an anaerobic spore-forming pathogen that causes a serious
toxin-mediated enteric disease in humans. Therapeutic agents that are capable of reducing …