Thymocyte development requires an integration of extracellular cues to enforce lineage
commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from …

The β-selection checkpoint in αβT lymphocyte development occurs at the double negative
(DN) 3 (CD4− CD8− CD25+ c-kit−) stage, when further differentiation requires a signal from …

Abstract The PI3K‐AKT pathway can mediate diverse biological responses and is crucial for
optimal immune responses and lymphocyte development. Deletion of PI3K subunits or AKT …

The role of PI3K activity in T lymphocyte development is obscure because mice deficient in
single PI3K catalytic subunits either die before birth (p110α−/− and p110β−/−) or lack a …

Pre-TCR signals regulate the transition of the double-negative (DN) 3 thymocytes to the
DN4, and subsequently to the double-positive (DP) stage. In this study, we show that pre …

T cell development is regulated at two critical checkpoints that involve signaling events
through the TCR. These signals are propagated by kinases of the Src and Syk families …

The first checkpoint in T cell development occurs between the CD4− CD8− and CD4+ CD8+
stages and is associated with formation of the pre-T cell receptor (TCR). The signaling …

Two major lineage decisions face immature T cells as they develop in the thymus. At an
early stage in their development, they must first commit to either the γδ or αβ lineages. If they …

Abstract Class 1 phosphoinositide 3-kinases (PI3Ks), consisting of PI3Kα, β, γ, and δ, are a
family of intracellular signaling molecules that play important roles in cell-mediated immune …

T cell receptor signaling allows the developing thymocyte to undergo positive or negative
selection, which is required for the formation of a useful mature T cell repertoire. Recent …