Mucous metaplasia (MM) is an aberrant secretory phenotype that arises during Helicobacter-
induced gastric carcinogenesis. HSPA5, a key modulator of the unfolded protein response …

Abstract Spasmolytic polypeptide (TFF2)-expressing metaplasia (SPEM) is observed in
mucosa adjacent to human gastric cancer and in fundic glands showing oxyntic atrophy in …

Subjected to countless daily injuries, the stomach still functions as a remarkably efficient
digestive organ and microbial filter. In this Review, we follow the lead of the earliest …

Metaplastic cell lineages arising in response to chronic injury are precursors for the
evolution of dysplasia and adenocarcinoma. Although a subtype of intestinal metaplasia has …

Objective Metaplasia arises from differentiated cell types in response to injury and is
considered a precursor in many cancers. Heterogeneous cell lineages are present in the …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Chronic Helicobacter pylori infection triggers neoplastic transformation of the gastric mucosa
in a small subset of patients, but the risk factors that induce progression to gastric metaplasia …

Background & Aims During aging, physiological changes in the stomach result in more
tenuous gastric tissue that is less capable of repairing injury, leading to increased …

Background & Aims Loss of parietal cells causes the development of spasmolytic
polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief cells. In the …

The myeloid differentiation factor Schlafen4 (Slfn4) marks a subset of myeloid-derived
suppressor cells (MDSCs) in the stomach during Helicobacter-induced spasmolytic …