Objective: Cholesterol is an important molecule in humans and both its excess and its
deficiency cause disease. Most clinicians appreciate its role in stabilizing cellular plasma …

27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation
and promotes breast cancer cell proliferation. Although lung is one of the organs that contain …

Tumor cells show high avidity for cholesterol in order to support their inherent nature to
divide and proliferate. This results in the rewiring of cholesterol homeostatic pathways by …

The oxysterol receptor LXR is a key transcriptional regulator of lipid metabolism. LXR
increases expression of SREBP-1, which in turn regulates at least 32 genes involved in lipid …

Atherosclerosis is the most common cause of mortality in the Western world, contributing to
about 50% of all deaths. Atherosclerosis is characterized by deposition of lipids onto the …

Cardiovascular diseases (atherosclerosis, stroke, myocardiac infarction etc.) are the major
systemic diseases of elder peoples in the world. This is possibly due to increased levels of …

Oxysterols are oxygenated derivatives of cholesterol generated from exogenous (food) or
endogenous (auto-oxidation and enzymatic conversion) sources. Despite their hepatic …

Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

The human brain is the most cholesterol-rich organ harboring 25% of the total cholesterol
pool of the whole body. Cholesterol present in the central nervous system (CNS) comes …

Cholesterol has evolved to fulfill sophisticated biophysical, cell signalling, and endocrine
functions in animal systems. At the cellular level, cholesterol is found in membranes where it …