Bone morphogenetic proteins (BMP‐2 and BMP‐3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3‐E1 …

Y Hiraki, H Inoue, C Shigeno, Y Sanma… - Journal of Bone and …, 1991 - Wiley Online Library
We studied the effects of highly purified bone morphogenetic protein 2 and 3 (BMP‐2 and−
3) on growth plate chondrocytes and osteoblastic cells in vitro and compared to TGF‐β. A …

Overexpression of BMP-2 modulates morphology, growth, and gene expression in osteoblastic cells

W Huang, GH Rudkin, B Carlsen, K Ishida… - Experimental cell …, 2002 - Elsevier
Bone morphogenetic proteins (BMP) play a pivotal role in growth and differentiation of
osteoblastic lineage cells. BMPs are potent stimulators of bone formation in various animal …

[HTML][HTML] Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation

F Kugimiya, H Kawaguchi, S Kamekura… - Journal of Biological …, 2005 - ASBMB
Although accumulated evidence has shown the bone anabolic effects of bone
morphogenetic proteins (BMPs) that were exogenously applied in vitro and in vivo, the roles …

Recombinant bone morphogenetic protein (BMP)‐2 regulates costochondral growth plate chondrocytes and induces expression of BMP‐2 and BMP‐4 in a cell …

DM Erickson, SE Harris, DD Dean… - Journal of …, 1997 - Wiley Online Library
This study examined the effect of recombinant human bone morphogenetic protein‐2 on
several parameters of growth, differentiation, and matrix synthesis and on the endogenous …

Subtle differences in the mitogenic effects of recombinant human bone morphogenetic proteins− 2 to− 7 on DNA synthesis on primary bone-forming cells and …

H Mayer, AM Scutt, T Ankenbauer - Calcified tissue international, 1996 - Springer
The bone morphogenetic proteins (BMPs) are a group of related proteins capable of
inducing the formation of new cartilage and bone. We report here a direct comparison of …

Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3

JA Tabas, M Zasloff, JJ Wasmuth, BS Emanuel… - Genomics, 1991 - Elsevier
Bone morphogenetic protein (BMP) induces endochondral bone formation in vivo. The
human genes have been cloned for a group of proteins containing BMP activity (BMP1 …

Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells

HH Luu, WX Song, X Luo, D Manning… - Journal of …, 2007 - Wiley Online Library
Efficacious bone regeneration could revolutionize the clinical management of many bone
and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can regulate the …

Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth …

P Chen, JL Carrington, RG Hammonds… - Experimental cell …, 1991 - Elsevier
Bone morphogenetic protein 2B (BMP-2B) also called BMP-4 is one of a family of cartilage
and bone-inductive proteins derived from bone matrix and belongs to the transforming …

A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7

GV Hahn, RB Cohen, JM Wozney, CL Levitz, EM Shore… - Genomics, 1992 - Elsevier
Bone morphogenetic proteins (BMPs) were originally identified by the ability of a
demineralized bone extract to induce endochondral osteogenesis in vivo. Seven BMP …

Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells

H Akiyama, C Shukunami, T Nakamura… - Cell structure and …, 2000 - jstage.jst.go.jp
Clonal cell line ATDC5 enables the monitoring of the early-and late-phase chondrogenic
differentiation in a single culture. Undifferentiated ATDC5 cells differentiate into type II …