Morbidity and mortality from opioid use disorders (OUD) and other substance use disorders
(SUD) is a major public health crisis, yet there are few medications to treat them. There is an …

Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …

Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued
and compulsive use of opioids despite harmful consequences. The development of …

Drug repurposing is the identification of novel indication (s) for existing medications. Health
claims data provide a burgeoning resource to evaluate pharmacotherapies with repurposing …

CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering
therapeutics. The limited understanding of the mechanisms driving these illnesses with the …

Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the
discovery of new applications of approved or investigational drugs. Among the …

Importance No existing model allows clinicians to predict whether patients might return to
opioid use in the early stages of treatment for opioid use disorder. Objective To develop an …

Introduction Opioid use disorder (OUD) is characterized by a problematic pattern of opioid
use leading to clinically-significant impairment or distress. Opioid agonist treatment is an …

Background and aims Cocaine use disorder (CUD) is a significant public health issue for
which there is no Food and Drug Administration (FDA) approved medication. Drug …

Background Buprenorphine is a widely used treatment option for patients with opioid use
disorder (OUD). Premature discontinuation from this treatment has many negative health …