Glutamate is a commercially important chemical. It is used as a flavor enhancer and is a
major raw material for producing industrially useful chemicals. A coryneform bacterium …

The nonpathogenic coryneform bacterium, Corynebacterium glutamicum, was isolated as an
l-glutamate-overproducing microorganism by Japanese researchers and is currently utilized …

Abstract l-Glutamic acid (l-Glu) is an industrially important amino acid for the production of
the flavor enhancer, monosodium-l-glutamate (MSG), which expresses a savory taste known …

We recently showed that the activity of the 2-oxoglutarate dehydrogenase complex (ODHC)
in Corynebacterium glutamicum is controlled by a novel regulatory mechanism that involves …

Traditionally, microbial strain development has relied on mutagenesis followed by a variety
of selection procedures to optimize production of metabolites. Such techniques, even though …

The mechanism of l-glutamate-overproduction by Corynebacterium glutamicum, a biotin
auxotroph, is very unique and interesting. l-Glutamate overproduction by this bacterium is …

Aim: The ultimate aim is to elucidate the molecular mechanisms for glutamate
overproduction by Corynebacterium glutamicum. Methods and Results: Gene expression in …

Since the discovery of Corynebacterium glutamicum as an efficient glutamate-overproducing
microorganism in 1957, the production of l-amino acids by the fermentative method has …

Glutamate production is a typical success in industrial fermentation. Annual production of
glutamate by Corynebacterium glutamicum is over 1.5 million tons per year worldwide. It is …

Overproduction of glutamate by Corynebacterium glutamicum is induced by biotin limitation
or by the supplementation of specific detergents, sublethal amounts of penicillin, or …