Microglia survey the brain microenvironment for signals of injury or infection and are
essential for the initiation and resolution of pathogen‐or tissue damage‐induced …

Microglia, the resident immune cells of the central nervous system, responds to brain
disarrangements by becoming activated to contend with brain damage. Here we show that …

Objective: To investigate and measure the functional significance of altered P2Y12
expression in the context of human microglia activation. Methods: We performed in vitro and …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous
system that leads to the progressive disability of patients. A characteristic feature of the …

Parkinson's disease (PD) is a common neurodegenerative disorder, which is characterized
by the selective and progressive death of dopaminergic (DA) neurons in the substantia …

Inflammation may contribute to multiple brain pathologies. One cause of inflammation is
lipopolysaccharide/endotoxin (LPS), the levels of which are elevated in blood and/or brain …

We investigated the involvement and roles of the ionotropic purinergic receptor P2X7R in
microglia in mediating lipopolysaccharide (LPS)-induced inflammatory responses and …

The release and extracellular action of ATP are a widespread mechanism for cell-to-cell
communication in living organisms through activation of P2X and P2Y receptors expressed …

Microglia are resident immune cells in the central nervous system that become activated and
produce pro‐inflammatory and neurotrophic factors upon activation of various cell‐surface …