Role of oxidative stress in amiodarone-induced toxicity
JSM Sarma, H Pei… - Journal of Cardiovascular …, 1997 - journals.sagepub.com
Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …
The role of free radicals in the pathogenesis of amiodarone toxicity
A Vereckei, A Blazovics, I Gyorgy… - Journal of …, 1993 - Wiley Online Library
Free Radicals and Amiodarone Toxicity. Introduction: In vitro and in vivo studies were
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …
Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro
RG Leeder, E Rafeiro, JF Brien… - Journal of …, 1996 - Wiley Online Library
Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …
Amiodarone-induced injury of human pulmonary artery endothelial cells: protection by alpha-tocopherol.
DL Kachel, TP Moyer, WJ Martin - Journal of Pharmacology and …, 1990 - ASPET
Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …
Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster
E Rafeiro, RG Leeder, JF Brien, GW Kabalka… - Toxicology and applied …, 1994 - Elsevier
Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity
PT Pollak, AD Sharma, SG Carruthers - The American journal of cardiology, 1990 - Elsevier
Hepatic enzymes, pulmonary function, serum amiodarone and desethylamiodarone (DEA)
concentrations and erythrocyte superoxide dismutase (SOD) activity were monitored at …
concentrations and erythrocyte superoxide dismutase (SOD) activity were monitored at …
Amiodarone-induced lymphocyte toxicity and mitochondrial function
SU Yasuda, EA Sausville, JB Hutchins… - Journal of …, 1996 - journals.lww.com
Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …
An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity
MJ Reasor, S Kacew - Proceedings of the Society for …, 1996 - journals.sagepub.com
The effectiveness of amiodarone in the treatment of cardiac arrhythmias is limited due to the
development of pulmonary toxicity. Although the biochemical and morphologic …
development of pulmonary toxicity. Although the biochemical and morphologic …
Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster
RG Leeder, JF Brien, TE Massey - Canadian journal of …, 1994 - cdnsciencepub.com
Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …
Amiodarone pulmonary toxicity: morphologic and biochemical features
MJ Reasor, S Kacew - Proceedings of the Society for …, 1991 - journals.sagepub.com
Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …
underlying serious adverse effects remain to be resolved and still limit drug usefulness …