[HTML][HTML] Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
J Doritchamou, P Bigey, MA Nielsen, S Gnidehou… - Vaccine, 2013 - Elsevier
Background VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …
[HTML][HTML] A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
[HTML][HTML] Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under …
Background Pregnancy-associated malaria (PAM) is a serious consequence of the
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …
[HTML][HTML] Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
The NTS-DBL2X Region of VAR2CSA Induces Cross-Reactive Antibodies That Inhibit Adhesion of Several Plasmodium falciparum Isolates to Chondroitin Sulfate A
P Bigey, S Gnidehou, J Doritchamou… - Journal of Infectious …, 2011 - academic.oup.com
Background. Binding to chondroitin sulfate A by VAR2CSA, a parasite protein expressed on
infected erythrocytes, allows placental sequestration of Plasmodium falciparum–infected …
infected erythrocytes, allows placental sequestration of Plasmodium falciparum–infected …
[HTML][HTML] Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
A Chêne, S Gangnard, C Dechavanne, S Dechavanne… - NPJ vaccines, 2018 - nature.com
Over 50 million women are exposed to the risk of malaria during pregnancy every year.
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
[HTML][HTML] Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
[HTML][HTML] The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium …
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
[HTML][HTML] Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
L Barfod, T Dobrilovic, P Magistrado… - The Journal of …, 2010 - journals.aai.org
Acquired protection from Plasmodium falciparum placental malaria, a major cause of
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …